A response regulator of the OmpR family is part of the regulatory network controlling the oxidative stress response of Rhodobacter sphaeroides.
Zhiping ZhaoTao PengJeong-Il OhJens GlaeserLennart WeberQingfeng LiGabriele KlugPublished in: Environmental microbiology reports (2018)
As a free-living bacterium Rhodobacter sphaeroides needs to respond to many environmental stresses. Oxidative stress, membrane stress or heat stress induce the ompR-1 gene encoding a protein of the OmpR family. Overexpression of OmpR-1 results in increased resistance to organic peroxides and diamide. Our data demonstrate that OmpR-1 positively affects expression of several sRNAs with an established role in R. sphaeroides stress defences and negatively affects the promoter of the rpoHI gene. The RpoHI sigma factor has a main role in the activation of many stress responses. Thus OmpR-1 has a balancing effect on the activation of the RpoHI regulon. We present a model with OmpR-1 as part of a regulatory network controlling stress defences in R. sphaeroides.
Keyphrases
- heat stress
- transcription factor
- oxidative stress
- dna methylation
- poor prognosis
- genome wide
- gene expression
- copy number
- heat shock
- stress induced
- binding protein
- machine learning
- electronic health record
- ischemia reperfusion injury
- deep learning
- signaling pathway
- endoplasmic reticulum stress
- protein protein
- induced apoptosis
- genome wide analysis
- long non coding rna