Pig endothelial protein C receptor is functionally compatible with the human protein C pathway.

Evelyn J SalvarisChristopher J MoranJean Christian RousselNella FisicaroSimon C RobsonPeter J Cowan

Published in: Xenotransplantation (2019)

Our data show that pEPCR is largely compatible with the human TBM/thrombin complex, when expressed on COS-7 cells in vitro, promoting the activation of human protein C. These findings suggest that endogenous pEPCR will enhance the activity of transgenic hTBM in the xenograft setting.

Keyphrases

endothelial cells
induced pluripotent stem cells
pluripotent stem cells
protein protein
binding protein
oxidative stress
cell proliferation
machine learning
signaling pathway
cell death
pi k akt