MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion.

Milind D ChalishazarSarah J WaitFang HuangAbbie S IrelandAnandaroop MukhopadhyayYounjee LeeSophia S SchumanMatthew R GuthrieKristofer C BerrettJeffery M VahrenkampZeping HuMarek KudlaKatarzyna ModzelewskaGuoying WangNicholas T IngoliaJason GertzDavid H LumSabina C CosulichJohn S BomalaskiRalph J DeBerardinisTrudy G Oliver

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

These data identify metabolic heterogeneity within SCLC and suggest arginine deprivation as a subtype-specific therapeutic vulnerability for MYC-driven SCLC.

Keyphrases

small cell lung cancer
nitric oxide
transcription factor
climate change
electronic health record
single cell
amino acid
big data
brain metastases
data analysis