Molecular Correlates of Topiramate and GRIK1 rs2832407 Genotype in Pluripotent Stem Cell-Derived Neural Cultures.

Richard LiebermanKevin P JensenKaitlin ClintonEric S LevineHenry R KranzlerJonathan M Covault

Published in: Alcoholism, clinical and experimental research (2020)

This work highlights the use of iPSC technologies to study pharmacogenetic treatment effects in psychiatric disorders and furthers our understanding of the molecular effects of topiramate exposure in human neural cells.

Keyphrases

induced apoptosis
induced pluripotent stem cells
endothelial cells
single molecule
endoplasmic reticulum stress
signaling pathway
pluripotent stem cells
cell proliferation
smoking cessation