Tissue-Specific Dependence of Th1 Cells on the Amino Acid Transporter SLC38A1 in Inflammation.

Ayaka SugiuraKatherine L BeierChanning ChiDarren R HeintzmanXiang YeMelissa M WolfAndrew R PattersonJacqueline-Yvonne CephusHanna S HongCostas Andreas Lyssiotis Dawn C Newcomb Jeffrey C Rathmell

Published in: bioRxiv : the preprint server for biology (2023)

T cells dynamically regulate glutamine amino acid transporters when activatedSLC38A1 supports Th1 cell mTORC1 and proliferation by redox and hexosamine pathwaysTargeting SLC38A1 does not affect lung inflammation but delays IBD and EAENutrient transporter needs of T cell subsets vary based on disease and tissue site.

Keyphrases

amino acid
oxidative stress
induced apoptosis
signaling pathway
cell cycle arrest
single cell
cell therapy
cell death
cell proliferation
ulcerative colitis