Imaging outcome measures of neuroprotection and repair in MS: A consensus statement from NAIMS.
Jiwon OhDaniel OntanedaChristina J AzevedoEric C KlawiterMartina AbsintaDouglas L ArnoldRohit BakshiPeter A CalabresiCiprian CrainiceanuBlake E DeweyLeorah FreemanSusan A GauthierRoland G HenryMathilde IngleseShannon H KolindDavid Wan-Cheng LiCaterina MaineroRavi S MenonGovind NairSridar NarayananFlavia NelsonDaniel PelletierAlexander RauscherWilliam RooneyPascal SatiDaniel SchwartzRussell Taki ShinoharaIan J TaggeAnthony L TraboulseeYi WangYoungjin YooTarek YousryYunyan ZhangNancy L SicotteDaniel S Reichnull nullPublished in: Neurology (2019)
Imaging biomarkers of neuroprotection and repair are an unmet need in MS. There are a number of promising techniques with different strengths and limitations, and selection of a specific technique will depend on a number of factors, notably the question the trial seeks to answer. Ongoing collaborative efforts will enable further refinement and improved methods to image the effect of novel therapeutic agents that exert benefit in MS predominately through neuroprotective and reparative mechanisms.