Child care closures have become pervasive in the U.S. due to the COVID-19 pandemic. Consequently, parents and caregivers' jobs have been affected as they have needed to care for children at home. This study estimated the burden of disrupted child care due to the COVID-19 pandemic and the pandemic's impact on employment among U.S. households between April and July 2021. Data came from the U.S. Census Bureau's Household Pulse Survey, Phase 3.1. The study sample included 55,312 households with any children in a child care arrangement. We estimated the prevalence of disrupted child care overall and by select sociodemographic and household characteristics as well as employment impacts among households that experienced disrupted child care. Overall, 20.4% (95% confidence interval: 19.1, 21.7) of U.S. households experienced disrupted child care; percentages varied by state from a low of 7.7% in Utah to a high of 29.4% in the District of Columbia. The prevalence of disrupted child care was highest among non-Hispanic Asian/Pacific Islander, non-Hispanic Black, low-income, and households that experienced material hardship. Adults were most likely to report supervising children while working, cutting work hours, and taking unpaid leave due to disruptions in child care. Continued support to the child care industry and to families with children may reduce the impacts of disrupted child care.