Serum and blister-fluid elevation and decreased epidermal content of high-mobility group box 1 protein in drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.

Daniel F CarrC-W WangT BellónL ResselG NwikueV ShrivastavaW BergfeldA L JorgensenW-H ChungM Pirmohamed

Published in: The British journal of dermatology (2019)

Epidermal HMGB1 expression was decreased in SJS/TEN skin. Retained basal/suprabasal epidermal HMGB1 expression may exacerbate localized injury in SJS/TEN.

Keyphrases

drug induced
wound healing
liver injury
poor prognosis
binding protein
transcription factor
case report
adverse drug
protein protein