Protective Role of Short-Chain Fatty Acids against Ang- II-Induced Mitochondrial Dysfunction in Brain Endothelial Cells: A Potential Role of Heme Oxygenase 2.
Modar KassanYoungin KwonUndral MunkhsaikhanAmal M SahyounTauheed IshratMaría GalánAlexis A GonzalezAmmaar H AbidiAdam KassanKarima Ait-AissaPublished in: Antioxidants (Basel, Switzerland) (2023)
SCFAs treatment restored endothelial cells and mitochondrial function following Ang-II-induced oxidative stress. SCFAs exert these beneficial effects by acting on HO-2. Our results are opening the door for more studies to investigate the effect the of SCFAs/HO-2 axis on hypertension and obesity-induced cerebrovascular diseases.
Keyphrases
- high glucose
- endothelial cells
- diabetic rats
- fatty acid
- blood pressure
- angiotensin ii
- metabolic syndrome
- type diabetes
- drug induced
- weight loss
- hydrogen peroxide
- vascular endothelial growth factor
- resting state
- white matter
- cell proliferation
- brain injury
- physical activity
- functional connectivity
- subarachnoid hemorrhage
- case control