Isolating the impact of antipsychotic medication on metabolic health: Secondary analysis of a randomized controlled trial of antipsychotic medication versus placebo in antipsychotic medication naïve first-episode psychosis (the STAGES study).
O'Donoghue BrianKelly A AllottSusy HarriganFranco ScalzoJanine WardSumudu MallawaarachchiSarah WhitsonLara BaldwinJessica GrahamEdward MullenCraig A MacneilDylan AlexanderStephen J WoodMichael BerkMario Alvarez-JimenezAndrew ThompsonAlex FornitoHok Pan YuenBarnaby NelsonShona M FranceyPatrick McGorryPublished in: Early intervention in psychiatry (2022)
While limited by small numbers and high attrition, these findings indicate that some of the metabolic complications observed in psychotic disorders could be attributable to factors other than medication. This emphasizes the need to deliver physical health interventions early in the course of FEP.