Viral-mediated oligodendroglial alpha-synuclein expression models multiple system atrophy.

Fares BassilPaul A GuerinNathalie DutheilQin LiMatthias KlugmannWassillios G MeissnerErwan BezardPierre-Olivier Fernagut

Published in: Movement disorders : official journal of the Movement Disorder Society (2017)

Viral-mediated oligodendroglial expression of α-synuclein allows replicating some of the key features of MSA. This flexible strategy can be used to investigate, in several species, how α-synuclein accumulation in selected oligodendroglial populations contributes to the pathophysiology of MSA and offers a new framework for preclinical validation of therapeutic strategies. © 2017 International Parkinson and Movement Disorder Society.

Keyphrases

poor prognosis
sars cov
binding protein
long non coding rna
cell therapy
stem cells
genetic diversity
mesenchymal stem cells