Duodenal Mucosal Expression of COVID-19-Related Genes in Health, Diabetic Gastroenteropathy, and Functional Dyspepsia.
Brototo DebDaniel R O'BrienZainali S ChunawalaAdil E BharuchaPublished in: The Journal of clinical endocrinology and metabolism (2022)
Several SARS-CoV-2-related genes were differentially expressed between DGE vs healthy controls and vs FD but not between DGE patients with normal vs delayed GE, suggesting that the differential expression is related to diabetes per se. The upregulation of CTSL and CTSB and replication genes may predispose to SARS-CoV2 infection of the gastrointestinal tract in diabetes.
Keyphrases
- sars cov
- type diabetes
- respiratory syndrome coronavirus
- poor prognosis
- cardiovascular disease
- glycemic control
- coronavirus disease
- public health
- healthcare
- long non coding rna
- helicobacter pylori infection
- genome wide
- signaling pathway
- binding protein
- metabolic syndrome
- risk assessment
- climate change
- insulin resistance
- transcription factor
- adipose tissue
- weight loss