Longitudinal Tau Positron Emission Tomography in Dementia with Lewy Bodies.
Qin ChenScott A PrzybelskiMatthew L SenjemChristopher G SchwarzTimothy G LesnickHugo BothaDavid S KnopmanJonathan Graff-RadfordRodolfo SavicaDavid T JonesJulie A FieldsManoj K JainNeill R Graff-RadfordTanis J FermanWalter K KremersClifford R JackRonald C PetersenBradley F BoeveVal J LoweKejal KantarciPublished in: Movement disorders : official journal of the Movement Disorder Society (2022)
Tau accumulation was faster in DLB compared with the CU, with increased accumulation rates in the lateral occipital and temporoparietal cortices. These increased rates of tau accumulation were associated with neurodegeneration and faster disease progression in DLB. Tau may be a potential treatment target in a subset of patients with DLB. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.