Viral infection-related gene upregulation in monocytes in children with signs of β-cell autoimmunity.

Milla Valta Masahito YoshiharaElisabet EinarsdottirSirpa PahkuriSini EzerShintaro KatayamaOlli H Laitinen Riitta VeijolaJorma ToppariJorma IlonenJuha KereJohanna Lempainen

Published in: Pediatric diabetes (2022)

Gene set enrichment analysis of children with T1D-associated autoimmunity revealed changes in pathways relevant for virus infection in PBMCs, particularly in monocytes. Virus infections have been repeatedly implicated in the pathogenesis of T1D. These results support the viral hypothesis by suggesting altered immune activation of viral immune pathways in monocytes during diabetes.

Keyphrases

young adults
dendritic cells
single cell
sars cov
peripheral blood
genome wide
copy number
type diabetes
cardiovascular disease
genome wide identification
cell proliferation
stem cells
cell therapy
poor prognosis
gene expression
dna methylation
metabolic syndrome
glycemic control
drug induced