Randomization of endovascular treatment with stent-retriever and/or thromboaspiration versus best medical therapy in acute ischemic stroke due to large vessel occlusion trial: Rationale and design.
Raul G NogueiraFabricio O LimaOctávio M Pontes-NetoGisele S SilvaFrancisco José Mont'AlverneDaniel G AbudMichel FruditPaulo PassosDiogo C HaussenGuilherme DabusGabriel R de FreitasJamary Oliveira-FilhoDaniel C BezerraDavid S LiebeskindMario B WagnerJosé Ef PassosCarlos A MolinaJoseph BroderickJeffrey L SaverSheila Cristina Ouriques MartinsPublished in: International journal of stroke : official journal of the International Stroke Society (2019)
Secondary end-points include: 90-day functional independence (mRS ≤2), mRS shift stratified for treatment with IV rt-PA at 90 days, infarct volume on 24 h CT or MRI, early dramatic response (NIHSS 0-2 or improvement ≥8 points) at 24 h, vessel recanalization evaluated by CTA or MRA at 24 h, and the post-procedure rate of successful reperfusion (defined as a modified Treatment in Cerebral Infarction 2b or greater). Safety variables are mortality at 90 days, symptomatic intracranial hemorrhage at 24 h and procedure-related complications.
Keyphrases
- endovascular treatment
- contrast enhanced
- acute myocardial infarction
- magnetic resonance imaging
- healthcare
- minimally invasive
- randomized controlled trial
- type diabetes
- magnetic resonance
- brain injury
- combination therapy
- bone marrow
- atrial fibrillation
- subarachnoid hemorrhage
- blood brain barrier
- image quality
- percutaneous coronary intervention
- cell therapy
- pet ct