Voxel-based correlation of 18F-THK5351 accumulation and gray matter volume in the brain of cognitively normal older adults.

Yoko ShigemotoDaichi SoneMiho OtaNorihide MaikusaMasayo OgawaKyoji OkitaHarumasa TakanoKoichi KatoYukio KimuraEmiko MorimotoFumio SuzukiHiroyuki FujiiNoriko SatoHiroshi Matsuda

Published in: EJNMMI research (2019)

Voxel-wise correlation analysis revealed a significant negative correlation between 18F-THK5351 accumulation and GM volume in the medial temporal lobe in individuals without amyloid-β deposits. These results may contribute to a better understanding of the pathophysiology of primary age-related tauopathy in human aging.

Keyphrases

endothelial cells
white matter
cognitive decline
induced pluripotent stem cells
mild cognitive impairment
pluripotent stem cells
multiple sclerosis
cerebral ischemia