Evaluation of the geographical utility of Eastern Russell's viper (Daboia siamensis) antivenom from Thailand and an assessment of its protective effects against venom-induced nephrotoxicity.

Janeyuth ChaisakulJaffer AlsolaissMongkon CharoenpitakchaiKulachet WiwatwarayosNattapon SookprasertRobert A HarrisonNarongsak ChaiyabutrLawan ChanhomeChoo Hock TanNicholas R Casewell

Published in: PLoS neglected tropical diseases (2019)

This study highlights the potential broad geographical utility of the Thai D. siamensis monovalent antivenom for treating envenomings by the Eastern Russell's viper. However, only the early delivery of high antivenom doses appears to be capable of preventing venom-induced nephrotoxicity.

Keyphrases

drug induced
high glucose
diabetic rats
south africa
oxidative stress
stress induced