Nicholas R Casewell (N R Casewell, Nicholas Casewell)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 86

Top Venues

Toxins

Nature communications

PLoS neglected tropical diseases

Proceedings of the National Academy of Sciences of the United States of America

Liverpool School of Tropical Medicine

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Liverpool School of Tropical Medicine

United Kingdom

Professor of Tropical Disease Biology :: Centre for Snakebite Research and Interventions

Publications

Haifeng Xu, Jesse Mastenbroek, Natascha T B Krikke, Susan El-Asal, Rama Mutlaq, Nicholas R Casewell, Julien Slagboom, Jeroen Kool
Nanofractionation Analytics for Comparing MALDI-MS and ESI-MS Data of Viperidae Snake Venom Toxins. Toxins 16 (8) (2024)
Susana Vázquez Torres, Melisa Benard Valle, Stephen P Mackessy, Stefanie K Menzies, Nicholas R Casewell, Shirin Ahmadi, Nick J Burlet, Edin Muratspahić, Isaac Sappington, Max D Overath, Esperanza Rivera-de-Torre, Jann Ledergerber, Andreas Hougaard Laustsen, Kim Boddum, Asim K Bera, Alex Kang, Evans Brackenbrough, Iara A Cardoso, Edouard P Crittenden, Rebecca J Edge, Justin Decarreau, Robert J Ragotte, Arvind S Pillai, Mohamad Abedi, Hannah L Han, Stacey R Gerben, Analisa Murray, Rebecca Skotheim, Lynda Stuart, Lance J Stewart, Thomas J A Fryer, Timothy Patrick Jenkins, Julien S Baker
De novo designed proteins neutralize lethal snake venom toxins. Research square (2024)
Irene S Khalek, R R Senji Laxme, Yen Thi Kim Nguyen, Suyog Khochare, Rohit N Patel, Jordan L Woehl, Jessica M Smith, Karen L Saye-Francisco, Yoojin Kim, Laetitia E Misson, Quoc Tran, Mateusz Kędzior, Evy Boré, Oliver Limbo, Megan Verma, Robyn L Stanfield, Stefanie K Menzies, Stuart Ainsworth, Robert A Harrison, Dennis R Burton, Devin Sok, Ian A Wilson, Nicholas R Casewell, Kartik Sunagar, Joseph G Jardine
Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins. Science translational medicine 16 (735) (2024)
Jaffer Alsolaiss, Gail Leeming, Rachael Da Silva, Nessrin Alomran, Nicholas R Casewell, Abdulrazaq G Habib, Robert A Harrison, Cassandra M Modahl
Investigating Snake-Venom-Induced Dermonecrosis and Inflammation Using an Ex Vivo Human Skin Model. Toxins 16 (6) (2024)
Susana Vázquez Torres, Melisa Benard Valle, Stephen P Mackessy, Stefanie K Menzies, Nicholas R Casewell, Shirin Ahmadi, Nick J Burlet, Edin Muratspahić, Isaac Sappington, Max D Overath, Esperanza Rivera-de-Torre, Jann Ledergerber, Andreas Hougaard Laustsen, Kim Boddum, Asim K Bera, Alex Kang, Evans Brackenbrough, Iara A Cardoso, Edouard P Crittenden, Rebecca J Edge, Justin Decarreau, Robert J Ragotte, Arvind S Pillai, Mohamad Abedi, Hannah L Han, Stacey R Gerben, Analisa Murray, Rebecca Skotheim, Lynda Stuart, Lance J Stewart, Thomas J A Fryer, Timothy Patrick Jenkins, Julien S Baker
De novo designed proteins neutralize lethal snake venom toxins. Research square (2024)
Keirah E Bartlett, Steven R Hall, Sean A Rasmussen, Edouard Crittenden, Charlotte A Dawson, Laura-Oana Albulescu, William Laprade, Robert A Harrison, Anthony J Saviola, Cassandra M Modahl, Timothy P Jenkins, Mark C Wilkinson, José María Gutiérrez, Nicholas R Casewell
Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib. Proceedings of the National Academy of Sciences of the United States of America 121 (19) (2024)
Haifeng Xu, Jesse Mastenbroek, Natascha T B Krikke, Susan El-Asal, Rama Mutlaq, Nicholas R Casewell, Julien Slagboom, Jeroen Kool
Nanofractionation Analytics for Comparing MALDI-MS and ESI-MS Data of Viperidae Snake Venom Toxins. Toxins 16 (8) (2024)
Tian Y Du, Steven R Hall, Felicity Chung, Sergey Kurdyukov, Edouard Crittenden, Karishma S Patel, Charlotte A Dawson, Adam P Westhorpe, Keirah E Bartlett, Sean A Rasmussen, Cesar L Moreno, Christopher E Denes, Laura-Oana Albulescu, Amy E Marriott, Joel P Mackay, Mark C Wilkinson, José María Gutiérrez, Nicholas R Casewell, G Gregory Neely
Molecular dissection of cobra venom highlights heparinoids as an antidote for spitting cobra envenoming. Science translational medicine 16 (756) (2024)
Irene S Khalek, R R Senji Laxme, Yen Thi Kim Nguyen, Suyog Khochare, Rohit N Patel, Jordan L Woehl, Jessica M Smith, Karen L Saye-Francisco, Yoojin Kim, Laetitia E Misson, Quoc Tran, Mateusz Kędzior, Evy Boré, Oliver Limbo, Megan Verma, Robyn L Stanfield, Stefanie K Menzies, Stuart Ainsworth, Robert A Harrison, Dennis R Burton, Devin Sok, Ian A Wilson, Nicholas R Casewell, Kartik Sunagar, Joseph G Jardine
Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins. Science translational medicine 16 (735) (2024)
Keirah E Bartlett, Steven R Hall, Sean A Rasmussen, Edouard Crittenden, Charlotte A Dawson, Laura-Oana Albulescu, William Laprade, Robert A Harrison, Anthony J Saviola, Cassandra M Modahl, Timothy P Jenkins, Mark C Wilkinson, José María Gutiérrez, Nicholas R Casewell
Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib. Proceedings of the National Academy of Sciences of the United States of America 121 (19) (2024)
Julien S Baker, Susana Vazquez Torres, Melisa Benard Valle, Stephen P Mackessy, Stefanie K Menzies, Nicholas R Casewell, Shirin Ahmadi, Nick J Burlet, Edin Muratspahić, Isaac Sappington, Max Overath, Esperanza Rivera-de-Torre, Jann Ledergerber, Andreas Hougaard Laustsen, Kim Boddum, Asim K Bera, Alex Kang, Evans Brackenbrough, Iara Cardoso, Edouard Crittenden, Rebecca Edge, Justin Decarreau, Robert Ragotte, Arvind S Pillai, Mohamad Abedi, Hannah L Han, Stacey R Gerben, Analisa Murray, Rebecca Skotheim, Lynda Stuart, Lance J Stewart, Thomas Fryer, Timothy Patrick Jenkins
De novo designed proteins neutralize lethal snake venom toxins. Research square (2024)
Laetitia E Misson, Jeffrey T Mindrebo, Quoc Tran, Mark C Wilkinson, Jessica M Smith, Megan Verma, Nicholas R Casewell, Gabriel C Lander, Joseph G Jardine
Importance of the Cysteine-Rich Domain of Snake Venom Prothrombin Activators: Insights Gained from Synthetic Neutralizing Antibodies. Toxins 16 (8) (2024)
Mátyás A Bittenbinder, Jory van Thiel, Fernanda C Cardoso, Nicholas R Casewell, José María Gutiérrez, Jeroen Kool, Freek J Vonk
Tissue damaging toxins in snake venoms: mechanisms of action, pathophysiology and treatment strategies. Communications biology 7 (1) (2024)
Laetitia E Misson, Jeffrey T Mindrebo, Quoc Tran, Mark C Wilkinson, Jessica M Smith, Megan Verma, Nicholas R Casewell, Gabriel C Lander, Joseph G Jardine
Importance of the Cysteine-Rich Domain of Snake Venom Prothrombin Activators: Insights Gained from Synthetic Neutralizing Antibodies. Toxins 16 (8) (2024)
Keirah E Bartlett, Steven R Hall, Sean A Rasmussen, Edouard Crittenden, Charlotte A Dawson, Laura-Oana Albulescu, William Laprade, Robert A Harrison, Anthony J Saviola, Cassandra M Modahl, Timothy P Jenkins, Mark C Wilkinson, José María Gutiérrez, Nicholas R Casewell
Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib. Proceedings of the National Academy of Sciences of the United States of America 121 (19) (2024)
Mátyás A Bittenbinder, Jory van Thiel, Fernanda C Cardoso, Nicholas R Casewell, José María Gutiérrez, Jeroen Kool, Freek J Vonk
Tissue damaging toxins in snake venoms: mechanisms of action, pathophysiology and treatment strategies. Communications biology 7 (1) (2024)
Mieke Nys, Eleftherios Zarkadas, Marijke Brams, Aujan Mehregan, Kumiko Kambara, Jeroen Kool, Nicholas R Casewell, Daniel Bertrand, John E Baenziger, Hugues Nury, Chris Ulens
Author Correction: The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors. Nature communications 15 (1) (2024)
Jaffer Alsolaiss, Gail Leeming, Rachael Da Silva, Nessrin Alomran, Nicholas R Casewell, Abdulrazaq G Habib, Robert A Harrison, Cassandra M Modahl
Investigating Snake-Venom-Induced Dermonecrosis and Inflammation Using an Ex Vivo Human Skin Model. Toxins 16 (6) (2024)
Laetitia E Misson, Jeffrey T Mindrebo, Quoc Tran, Mark C Wilkinson, Jessica M Smith, Megan Verma, Nicholas R Casewell, Gabriel C Lander, Joseph G Jardine
Importance of the Cysteine-Rich Domain of Snake Venom Prothrombin Activators: Insights Gained from Synthetic Neutralizing Antibodies. Toxins 16 (8) (2024)
Jaffer Alsolaiss, Gail Leeming, Rachael Da Silva, Nessrin Alomran, Nicholas R Casewell, Abdulrazaq G Habib, Robert A Harrison, Cassandra M Modahl
Investigating Snake-Venom-Induced Dermonecrosis and Inflammation Using an Ex Vivo Human Skin Model. Toxins 16 (6) (2024)
Keirah E Bartlett, Steven R Hall, Sean A Rasmussen, Edouard Crittenden, Charlotte A Dawson, Laura-Oana Albulescu, William Laprade, Robert A Harrison, Anthony J Saviola, Cassandra M Modahl, Timothy P Jenkins, Mark C Wilkinson, José María Gutiérrez, Nicholas R Casewell
Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib. Proceedings of the National Academy of Sciences of the United States of America 121 (19) (2024)
Haifeng Xu, Jesse Mastenbroek, Natascha T B Krikke, Susan El-Asal, Rama Mutlaq, Nicholas R Casewell, Julien Slagboom, Jeroen Kool
Nanofractionation Analytics for Comparing MALDI-MS and ESI-MS Data of Viperidae Snake Venom Toxins. Toxins 16 (8) (2024)
Mieke Nys, Eleftherios Zarkadas, Marijke Brams, Aujan Mehregan, Kumiko Kambara, Jeroen Kool, Nicholas R Casewell, Daniel Bertrand, John E Baenziger, Hugues Nury, Chris Ulens
Author Correction: The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors. Nature communications 15 (1) (2024)
Fernanda Gobbi Amorim, Damien Redureau, Thomas Crasset, Lou Freuville, Dominique Baiwir, Gabriel Mazzucchelli, Stefanie K Menzies, Nicholas R Casewell, Loïc Quinton
Next-Generation Sequencing for Venomics: Application of Multi-Enzymatic Limited Digestion for Inventorying the Snake Venom Arsenal. Toxins 15 (6) (2023)
Steven R Hall, Sean A Rasmussen, Edouard Crittenden, Charlotte A Dawson, Keirah E Bartlett, Adam P Westhorpe, Laura-Oana Albulescu, Jeroen Kool, José María Gutiérrez, Nicholas R Casewell
Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms. Nature communications 14 (1) (2023)
Fernanda Gobbi Amorim, Damien Redureau, Thomas Crasset, Lou Freuville, Dominique Baiwir, Gabriel Mazzucchelli, Stefanie K Menzies, Nicholas R Casewell, Loïc Quinton
Next-Generation Sequencing for Venomics: Application of Multi-Enzymatic Limited Digestion for Inventorying the Snake Venom Arsenal. Toxins 15 (6) (2023)
Stefanie K Menzies, Raquel Arinto-Garcia, Fernanda Gobbi Amorim, Iara Aimê Cardoso, Camille Abada, Thomas Crasset, Fabien Durbesson, Rebecca J Edge, Priscila El-Kazzi, Sophie Hall, Damien Redureau, Richard Stenner, Johara Boldrini-França, Huan Sun, António Roldão, Paula M Alves, Robert A Harrison, Renaud Vincentelli, Imre Berger, Loïc Quinton, Nicholas R Casewell, Christiane Schaffitzel
ADDovenom: Thermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite Envenoming. Toxins 15 (12) (2023)
Mátyás A Bittenbinder, Nick D Bergkamp, Julien Slagboom, Jan Paul M Bebelman, Nicholas R Casewell, Marco H Siderius, Martine J Smit, Jeroen Kool, Freek J Vonk
Monitoring Snake Venom-Induced Extracellular Matrix Degradation and Identifying Proteolytically Active Venom Toxins Using Fluorescently Labeled Substrates. Biology 12 (6) (2023)
Luis Lago Alonso, Julien Slagboom, Nicholas R Casewell, Saer Samanipour, Jeroen Kool
Metabolome-Based Classification of Snake Venoms by Bioinformatic Tools. Toxins 15 (2) (2023)
Steven R Hall, Sean A Rasmussen, Edouard Crittenden, Charlotte A Dawson, Keirah E Bartlett, Adam P Westhorpe, Laura-Oana Albulescu, Jeroen Kool, José María Gutiérrez, Nicholas R Casewell
Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms. Nature communications 14 (1) (2023)
Steven R Hall, Sean A Rasmussen, Edouard Crittenden, Charlotte A Dawson, Keirah E Bartlett, Adam P Westhorpe, Laura-Oana Albulescu, Jeroen Kool, José María Gutiérrez, Nicholas R Casewell
Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms. Nature communications 14 (1) (2023)
Luis Lago Alonso, Julien Slagboom, Nicholas R Casewell, Saer Samanipour, Jeroen Kool
Metabolome-Based Classification of Snake Venoms by Bioinformatic Tools. Toxins 15 (2) (2023)
Eric Wachtel, Matyas A Bittenbinder, Bas van de Velde, Julien Slagboom, Axel de Monts de Savasse, Luis Lago Alonso, Nicholas R Casewell, Freek J Vonk, Jeroen Kool
Application of an Extracellular Matrix-Mimicking Fluorescent Polymer for the Detection of Proteolytic Venom Toxins. Toxins 15 (4) (2023)
Stefanie K Menzies, Raquel Arinto-Garcia, Fernanda Gobbi Amorim, Iara Aimê Cardoso, Camille Abada, Thomas Crasset, Fabien Durbesson, Rebecca J Edge, Priscila El-Kazzi, Sophie Hall, Damien Redureau, Richard Stenner, Johara Boldrini-França, Huan Sun, António Roldão, Paula M Alves, Robert A Harrison, Renaud Vincentelli, Imre Berger, Loïc Quinton, Nicholas R Casewell, Christiane Schaffitzel
ADDovenom: Thermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite Envenoming. Toxins 15 (12) (2023)
Luis Lago Alonso, Julien Slagboom, Nicholas R Casewell, Saer Samanipour, Jeroen Kool
Metabolome-Based Classification of Snake Venoms by Bioinformatic Tools. Toxins 15 (2) (2023)
Stefanie K Menzies, Raquel Arinto-Garcia, Fernanda Gobbi Amorim, Iara Aimê Cardoso, Camille Abada, Thomas Crasset, Fabien Durbesson, Rebecca J Edge, Priscila El-Kazzi, Sophie Hall, Damien Redureau, Richard Stenner, Johara Boldrini-França, Huan Sun, António Roldão, Paula M Alves, Robert A Harrison, Renaud Vincentelli, Imre Berger, Loïc Quinton, Nicholas R Casewell, Christiane Schaffitzel
ADDovenom: Thermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite Envenoming. Toxins 15 (12) (2023)
Luis Lago Alonso, Julien Slagboom, Nicholas R Casewell, Saer Samanipour, Jeroen Kool
Metabolome-Based Classification of Snake Venoms by Bioinformatic Tools. Toxins 15 (2) (2023)
Mátyás A Bittenbinder, Nick D Bergkamp, Julien Slagboom, Jan Paul M Bebelman, Nicholas R Casewell, Marco H Siderius, Martine J Smit, Jeroen Kool, Freek J Vonk
Monitoring Snake Venom-Induced Extracellular Matrix Degradation and Identifying Proteolytically Active Venom Toxins Using Fluorescently Labeled Substrates. Biology 12 (6) (2023)
Stefanie K Menzies, Raquel Arinto-Garcia, Fernanda Gobbi Amorim, Iara Aimê Cardoso, Camille Abada, Thomas Crasset, Fabien Durbesson, Rebecca J Edge, Priscila El-Kazzi, Sophie Hall, Damien Redureau, Richard Stenner, Johara Boldrini-França, Huan Sun, António Roldão, Paula M Alves, Robert A Harrison, Renaud Vincentelli, Imre Berger, Loïc Quinton, Nicholas R Casewell, Christiane Schaffitzel
ADDovenom: Thermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite Envenoming. Toxins 15 (12) (2023)
Luis Lago Alonso, Julien Slagboom, Nicholas R Casewell, Saer Samanipour, Jeroen Kool
Metabolome-Based Classification of Snake Venoms by Bioinformatic Tools. Toxins 15 (2) (2023)
Eric Wachtel, Matyas A Bittenbinder, Bas van de Velde, Julien Slagboom, Axel de Monts de Savasse, Luis Lago Alonso, Nicholas R Casewell, Freek J Vonk, Jeroen Kool
Application of an Extracellular Matrix-Mimicking Fluorescent Polymer for the Detection of Proteolytic Venom Toxins. Toxins 15 (4) (2023)
Fernanda Gobbi Amorim, Damien Redureau, Thomas Crasset, Lou Freuville, Dominique Baiwir, Gabriel Mazzucchelli, Stefanie K Menzies, Nicholas R Casewell, Loïc Quinton
Next-Generation Sequencing for Venomics: Application of Multi-Enzymatic Limited Digestion for Inventorying the Snake Venom Arsenal. Toxins 15 (6) (2023)
Steven R Hall, Sean A Rasmussen, Edouard Crittenden, Charlotte A Dawson, Keirah E Bartlett, Adam P Westhorpe, Laura-Oana Albulescu, Jeroen Kool, José María Gutiérrez, Nicholas R Casewell
Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms. Nature communications 14 (1) (2023)
Eric Wachtel, Matyas A Bittenbinder, Bas van de Velde, Julien Slagboom, Axel de Monts de Savasse, Luis Lago Alonso, Nicholas R Casewell, Freek J Vonk, Jeroen Kool
Application of an Extracellular Matrix-Mimicking Fluorescent Polymer for the Detection of Proteolytic Venom Toxins. Toxins 15 (4) (2023)
Fernanda Gobbi Amorim, Damien Redureau, Thomas Crasset, Lou Freuville, Dominique Baiwir, Gabriel Mazzucchelli, Stefanie K Menzies, Nicholas R Casewell, Loïc Quinton
Next-Generation Sequencing for Venomics: Application of Multi-Enzymatic Limited Digestion for Inventorying the Snake Venom Arsenal. Toxins 15 (6) (2023)
Eric Wachtel, Matyas A Bittenbinder, Bas van de Velde, Julien Slagboom, Axel de Monts de Savasse, Luis Lago Alonso, Nicholas R Casewell, Freek J Vonk, Jeroen Kool
Application of an Extracellular Matrix-Mimicking Fluorescent Polymer for the Detection of Proteolytic Venom Toxins. Toxins 15 (4) (2023)
Steven R Hall, Sean A Rasmussen, Edouard Crittenden, Charlotte A Dawson, Keirah E Bartlett, Adam P Westhorpe, Laura-Oana Albulescu, Jeroen Kool, José María Gutiérrez, Nicholas R Casewell
Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms. Nature communications 14 (1) (2023)
Eric Wachtel, Matyas A Bittenbinder, Bas van de Velde, Julien Slagboom, Axel de Monts de Savasse, Luis Lago Alonso, Nicholas R Casewell, Freek J Vonk, Jeroen Kool
Application of an Extracellular Matrix-Mimicking Fluorescent Polymer for the Detection of Proteolytic Venom Toxins. Toxins 15 (4) (2023)
Sedef Terzioglu, Mátyás A Bittenbinder, Julien Slagboom, Bas van de Velde, Nicholas R Casewell, Jeroen Kool
Analytical Size Exclusion Chromatography Coupled with Mass Spectrometry in Parallel with High-Throughput Venomics and Bioassaying for Venom Profiling. Toxins 15 (9) (2023)
David J Gower, James F Fleming, Davide Pisani, Freek J Vonk, Harald M I Kerkkamp, Leo Peichl, Sonja Meimann, Nicholas R Casewell, Christiaan V Henkel, Michael K Richardson, Kate L Sanders, Bruno F Simões
Eye-Transcriptome and Genome-Wide Sequencing for Scolecophidia: Implications for Inferring the Visual System of the Ancestral Snake. Genome biology and evolution 13 (12) (2022)
Jaffer Alsolaiss, Nessrin Alomran, Laura Hawkins, Nicholas R Casewell
Commercial Antivenoms Exert Broad Paraspecific Immunological Binding and In Vitro Inhibition of Medically Important Bothrops Pit Viper Venoms. Toxins 15 (1) (2022)
Michael Abouyannis, Richard FitzGerald, Mwanajuma Ngama, Hope Mwangudzah, Yvonne K Nyambura, Samson Ngome, Debra Riako, Lawrence Babu, Frida Lewa, Laura Else, Sujan Dily Penchala, Benedict Orindi, Noni Mumba, Betty Kalama, Francis M Ndungu, Ifedayo M O Adetifa, Saye Khoo, David Griffith Lalloo, Nicholas R Casewell, Mainga M Hamaluba
TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming phase 1 (safety, tolerability, pharmacokinetics and pharmacodynamics in healthy Kenyan adults). Wellcome open research 7 (2022)
Arif Arrahman, Taline D Kazandjian, Kristina B M Still, Julien Slagboom, Govert W Somsen, Freek J Vonk, Nicholas R Casewell, Jeroen Kool
A Combined Bioassay and Nanofractionation Approach to Investigate the Anticoagulant Toxins of Mamba and Cobra Venoms and Their Inhibition by Varespladib. Toxins 14 (11) (2022)
Jaffer Alsolaiss, Nessrin Alomran, Laura Hawkins, Nicholas R Casewell
Commercial Antivenoms Exert Broad Paraspecific Immunological Binding and In Vitro Inhibition of Medically Important Bothrops Pit Viper Venoms. Toxins 15 (1) (2022)
Jaffer Alsolaiss, Chloe A Evans, George O Oluoch, Nicholas R Casewell, Robert A Harrison
Profiling the Murine Acute Phase and Inflammatory Responses to African Snake Venom: An Approach to Inform Acute Snakebite Pathology. Toxins 14 (4) (2022)
Jaffer Alsolaiss, Nessrin Alomran, Laura Hawkins, Nicholas R Casewell
Commercial Antivenoms Exert Broad Paraspecific Immunological Binding and In Vitro Inhibition of Medically Important Bothrops Pit Viper Venoms. Toxins 15 (1) (2022)
Mieke Nys, Eleftherios Zarkadas, Marijke Brams, Aujan Mehregan, Kumiko Kambara, Jeroen Kool, Nicholas R Casewell, Daniel Bertrand, John E Baenziger, Hugues Nury, Chris Ulens
The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors. Nature communications 13 (1) (2022)
Nessrin Alomran, Raja Chinnappan, Jaffer Alsolaiss, Nicholas R Casewell, Mohammed M Zourob
Exploring the Utility of ssDNA Aptamers Directed against Snake Venom Toxins as New Therapeutics for Snakebite Envenoming. Toxins 14 (7) (2022)
Jaffer Alsolaiss, Nessrin Alomran, Laura Hawkins, Nicholas R Casewell
Commercial Antivenoms Exert Broad Paraspecific Immunological Binding and In Vitro Inhibition of Medically Important Bothrops Pit Viper Venoms. Toxins 15 (1) (2022)
Nessrin Alomran, Patricia Blundell, Jaffer Alsolaiss, Edouard Crittenden, Stuart Ainsworth, Charlotte A Dawson, Rebecca J Edge, Steven R Hall, Robert A Harrison, Mark C Wilkinson, Stefanie K Menzies, Nicholas R Casewell
Exploring the Utility of Recombinant Snake Venom Serine Protease Toxins as Immunogens for Generating Experimental Snakebite Antivenoms. Toxins 14 (7) (2022)
Taline D Kazandjian, Arif Arrahman, Kristina B M Still, Govert W Somsen, Freek J Vonk, Nicholas R Casewell, Mark C Wilkinson, Jeroen Kool
Anticoagulant Activity of Naja nigricollis Venom Is Mediated by Phospholipase A2 Toxins and Inhibited by Varespladib. Toxins 13 (5) (2021)
R R Senji Laxme, Suyog Khochare, Saurabh S Attarde, Vivek Suranse, Ashwin Iyer, Nicholas R Casewell, Romulus Whitaker, Gerard Martin, Kartik Sunagar
Biogeographic venom variation in Russell's viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots. PLoS neglected tropical diseases 15 (3) (2021)
Nessrin Alomran, Jaffer Alsolaiss, Laura-Oana Albulescu, Edouard Crittenden, Robert A Harrison, Stuart Ainsworth, Nicholas R Casewell
Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms. PLoS neglected tropical diseases 15 (8) (2021)
Ignazio Avella, Edgar Barajas-Ledesma, Nicholas R Casewell, Robert A Harrison, Paul D Rowley, Edouard Crittenden, Wolfgang Wüster, Riccardo Castiglia, Chris Holland, Arie van der Meijden
Unexpected lack of specialisation in the flow properties of spitting cobra venom. The Journal of experimental biology 224 (7) (2021)
José María Gutiérrez, Laura-Oana Albulescu, Rachel H Clare, Nicholas R Casewell, Tarek Mohamed Abd El-Aziz, Teresa Escalante, Alexandra Rucavado
The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming. Toxins 13 (7) (2021)
Taline D Kazandjian, Daniel Petras, Samuel D Robinson, Jory van Thiel, Harry W Greene, Kevin Arbuckle, A Barlow, David A Carter, Roel M Wouters, G Whiteley, Simon Wagstaff, Ana Silvia Arias, Laura-Oana Albulescu, A Plettenberg Laing, C Hall, A Heap, S Penrhyn-Lowe, C V McCabe, Stuart Ainsworth, Ricardo R da Silva, Pieter C Dorrestein, Michael K Richardson, José María Gutiérrez, Juan J Calvete, Robert A Harrison, Irina Vetter, Eivind A B Undheim, Wolfgang Wüster, Nicholas R Casewell
Convergent evolution of pain-inducing defensive venom components in spitting cobras. Science (New York, N.Y.) 371 (6527) (2021)
R R Senji Laxme, Saurabh S Attarde, Suyog Khochare, Vivek Suranse, Gerard Martin, Nicholas R Casewell, Romulus Whitaker, Kartik Sunagar
Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy. PLoS neglected tropical diseases 15 (2) (2021)
Ignazio Avella, Edgar Barajas-Ledesma, Nicholas R Casewell, Robert A Harrison, Paul D Rowley, Edouard Crittenden, Wolfgang Wüster, Riccardo Castiglia, Chris Holland, Arie van der Meijden
Unexpected lack of specialisation in the flow properties of spitting cobra venom. The Journal of experimental biology 224 (Pt 7) (2021)
Bianca Op den Brouw, Parviz Ghezellou, Nicholas R Casewell, Syed Abid Ali, Behzad Fathinia, Bryan Grieg Fry, Mettine H A Bos, Maria P Ikonomopoulou
Pharmacological Characterisation of Pseudocerastes and Eristicophis Viper Venoms Reveal Anticancer (Melanoma) Properties and a Potentially Novel Mode of Fibrinogenolysis. International journal of molecular sciences 22 (13) (2021)
Jens Puschhof, Yorick Post, Joep Beumer, Harald M Kerkkamp, Matyas Bittenbinder, Freek J Vonk, Nicholas R Casewell, Michael K Richardson, Hans Clevers
Derivation of snake venom gland organoids for in vitro venom production. Nature protocols 16 (3) (2021)
Laura-Oana Albulescu, Melissa S Hale, Stuart Ainsworth, Jaffer Alsolaiss, Edouard Crittenden, Juan J Calvete, Chloe Evans, Mark C Wilkinson, Robert A Harrison, Jeroen Kool, Nicholas R Casewell
Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite. Science translational medicine 12 (542) (2021)
Bianca Op den Brouw, Francisco C P Coimbra, Lachlan Allan Bourke, Tam Minh Huynh, Danielle H W Vlecken, Parviz Ghezellou, Jeroen C Visser, James S Dobson, Manuel A Fernandez-Rojo, Maria P Ikonomopoulou, Nicholas R Casewell, Syed A Ali, Behzad Fathinia, Wayne C Hodgson, Bryan Grieg Fry
Extensive Variation in the Activities of Pseudocerastes and Eristicophis Viper Venoms Suggests Divergent Envenoming Strategies Are Used for Prey Capture. Toxins 13 (2) (2021)
Laura-Oana Albulescu, Chunfang Xie, Stuart Ainsworth, Jaffer Alsolaiss, Edouard Crittenden, Charlotte A Dawson, Rowan Softley, Keirah E Bartlett, Robert A Harrison, Jeroen Kool, Nicholas R Casewell
Author Correction: A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite. Nature communications 12 (1) (2021)
Bianca Op den Brouw, Francisco C P Coimbra, Nicholas R Casewell, Syed Abid Ali, Freek J Vonk, Bryan Grieg Fry
A Genus-Wide Bioactivity Analysis of Daboia (Viperinae: Viperidae) Viper Venoms Reveals Widespread Variation in Haemotoxic Properties. International journal of molecular sciences 22 (24) (2021)
Cecilie Knudsen, Nicholas R Casewell, Bruno Lomonte, José María Gutiérrez, Sakthivel Vaiyapuri, Andreas Hougaard Laustsen
Novel Snakebite Therapeutics Must Be Tested in Appropriate Rescue Models to Robustly Assess Their Preclinical Efficacy. Toxins 12 (9) (2020)
Janeyuth Chaisakul, Muhamad Rusdi Ahmad Rusmili, Jaffer Alsolaiss, Laura-Oana Albulescu, Robert A Harrison, Iekhsan Othman, Nicholas R Casewell
In Vitro Immunological Cross-Reactivity of Thai Polyvalent and Monovalent Antivenoms with Asian Viper Venoms. Toxins 12 (12) (2020)
Brett R Hamilton, David L Marshall, Nicholas R Casewell, Robert A Harrison, Stephen J Blanksby, Eivind A B Undheim
Mapping Enzyme Activity on Tissue by Functional Mass Spectrometry Imaging. Angewandte Chemie (International ed. in English) 59 (10) (2020)
Stuart Ainsworth, Stefanie K Menzies, Nicholas R Casewell, Robert A Harrison
An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite treatment and management. PLoS neglected tropical diseases 14 (8) (2020)
Laura-Oana Albulescu, Chunfang Xie, Stuart Ainsworth, Jaffer Alsolaiss, Edouard Crittenden, Charlotte A Dawson, Rowan Softley, Keirah E Bartlett, Robert A Harrison, Jeroen Kool, Nicholas R Casewell
A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite. Nature communications 11 (1) (2020)
Kamille E Krause, Timothy Patrick Jenkins, Carina Skaarup, Mikael Engmark, Nicholas R Casewell, Stuart Ainsworth, Bruno Lomonte, Julián Fernández, José María Gutiérrez, Ole Lund, Andreas Hougaard Laustsen
An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity. PLoS neglected tropical diseases 14 (6) (2020)
Chunfang Xie, Laura-Oana Albulescu, Mátyás A Bittenbinder, Govert W Somsen, Freek J Vonk, Nicholas R Casewell, Jeroen Kool
Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic Viperinae Snake Venom Toxins. Biomedicines 8 (9) (2020)
Janeyuth Chaisakul, Jaffer Alsolaiss, Mongkon Charoenpitakchai, Kulachet Wiwatwarayos, Nattapon Sookprasert, Robert A Harrison, Narongsak Chaiyabutr, Lawan Chanhome, Choo Hock Tan, Nicholas R Casewell
Evaluation of the geographical utility of Eastern Russell's viper (Daboia siamensis) antivenom from Thailand and an assessment of its protective effects against venom-induced nephrotoxicity. PLoS neglected tropical diseases 13 (10) (2019)
Nicholas R Casewell, Daniel Petras, Daren C Card, Vivek Suranse, Alexis M Mychajliw, David Richards, Ivan Koludarov, Laura-Oana Albulescu, Julien Slagboom, Benjamin-Florian Hempel, Neville M Ngum, Rosalind J Kennerley, Jorge L Brocca, Gareth Whiteley, Robert A Harrison, Fiona M S Bolton, Jordan Debono, Freek J Vonk, Jessica Alföldi, Jeremy Johnson, Elinor K Karlsson, Kerstin Lindblad-Toh, Ian R Mellor, Roderich D Süssmuth, Bryan Grieg Fry, Sanjaya Kuruppu, Wayne C Hodgson, Jeroen Kool, Todd A Castoe, Ian Barnes, Kartik Sunagar, Eivind A B Undheim, Samuel T Turvey
Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals. Proceedings of the National Academy of Sciences of the United States of America 116 (51) (2019)
Stuart Ainsworth, Julien Slagboom, Nessrin Alomran, Davinia Pla, Yasir Alhamdi, Sarah I King, Fiona M S Bolton, José María Gutiérrez, Freek J Vonk, Cheng-Hock Toh, Juan J Calvete, Jeroen Kool, Robert A Harrison, Nicholas R Casewell
The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms. Communications biology 1 (2018)
Juan J Calvete, Nicholas R Casewell, U Hernández-Guzmán, S Quesada-Bernat, L Sanz, D R Rokyta, D Storey, L-O Albulescu, W Wüster, C F Smith, G W Schuett, Warren Booth
Venom Complexity in a Pitviper Produced by Facultative Parthenogenesis. Scientific reports 8 (1) (2018)
Julien Slagboom, Jeroen Kool, Robert A Harrison, Nicholas R Casewell
Haemotoxic snake venoms: their functional activity, impact on snakebite victims and pharmaceutical promise. British journal of haematology 177 (6) (2017)

Nicholas R Casewell.css-eqlu8i{font-size:small;padding-left:4px;} (N R Casewell, Nicholas Casewell)

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Nicholas R Casewell (N R Casewell, Nicholas Casewell)