Human gastric cancer modelling using organoids.

Therese SeidlitzSebastian R MerkerAlexander RotheFalk ZakrzewskiCläre von NeubeckKonrad GrützmannUlrich SommerChristine SchweitzerSebastian SchölchHeike UhlemannAnne-Marlene GaeblerKristin WernerMechthild KrauseGustavo B BarettonThilo WelschBon-Kyoung KooDaniela E AustBarbara KlinkJürgen WeitzDaniel E Stange

Published in: Gut (2018)

We generated human and mouse gastric cancer organoids modelling typical characteristics and altered pathways of human gastric cancer. Successful interference with activated pathways demonstrates their potential usefulness as living biomarkers for therapy response testing.

Keyphrases

endothelial cells
induced pluripotent stem cells
pluripotent stem cells
stem cells
risk assessment
smoking cessation