Multi-Niche Human Bone Marrow On-A-Chip for Studying the Interactions of Adoptive CAR-T Cell Therapies with Multiple Myeloma.

Delta GhoshalIngrid PetersenRachel RingquistLiana KramerEshant BhatiaThomas HuAriane RichardReda ParkJenna CorbinSavi AgarwalAbel ThomasSebastian RamirezJacob TharayilEmma DowneyFrank KetchumAbigail OchalNeha SonthiSagar LonialJames N KochenderferReginald TranMandy ZhuWilbur A LamAhmet F CoskunKrishnendu Roy

Published in: bioRxiv : the preprint server for biology (2024)

A multiple myeloma model can study why the disease is still challenging to treat despite options that work well in other cancers.

Keyphrases

multiple myeloma
bone marrow
endothelial cells
mesenchymal stem cells
cell therapy
high throughput
pluripotent stem cells
circulating tumor cells
single cell