Keeping an eye on circadian time in clinical research and medicine.
Elizabeth B KlermanAllison BragerMary A CarskadonChristopher M DepnerRussell G FosterNamni GoelMary E HarringtonPaul M HollowayMelissa P KnauertMonique K LeBourgeoisJonathan O LiptonMartha MerrowSara MontagneseMingming NingDavid W RayFrank A J L ScheerSteven A SheaDebra Jean SkeneClaudia D SpiesBart StaelsMarie-Pierre St-OngeSteffen TiedtPhyllis C ZeeHelen J BurgessPublished in: Clinical and translational medicine (2022)
Although circadian rhythms and daily effects on health outcomes can be challenging to distinguish in practice, this distinction may be important in many clinical settings. Identifying and targeting the appropriate underlying (patho)physiology is a medical goal. This review provides methods for identifying circadian effects to aid in the interpretation of published work and the inclusion of circadian factors in clinical research and practice.