Prognosis of non-small-cell lung cancer in patients with idiopathic pulmonary fibrosis.
SongYi HanYeon Joo LeeJong Sun ParkYoung Jae ChoHo Il YoonJae-Ho LeeChoon-Taek LeeJin-Haeng ChungKyung Won LeeSang Hoon LeePublished in: Scientific reports (2019)
The risk of lung cancer is higher in idiopathic pulmonary fibrosis (IPF) because both conditions share common risk factors. However, no standard treatment modality for LC in IPF exists due to rare incidence, poor prognosis, and acute exacerbation (AE) of IPF during treatment. We aimed to determine the efficacy of LC treatments and the prognosis in LC patients with IPF according to the LC stage and GAP (gender [G], age [A], and two physiology variables [P]) stage. From 2003 to 2016, 160 retrospectively enrolled patients were classified according to the LC clinical stage and GAP stage. The average (±standard deviation) patient age was 70.1 ± 8.2 years; the cohort predominantly comprised men (94.4%). In GAP stage I, surgery was significantly associated with better survival outcomes in LC. In contrast, no treatment modality yielded significant clinical improvement in GAP stage II/III. The incidences of AE in IPF and its mortality during treatment were 13.8% and 6.3%, respectively. AE occurred commonly in advanced GAP stage. Active treatment should be considered in GAP stage I. The performance status and LC stage should be considered when deciding about the necessity of surgery for patients in advanced GAP stage.
Keyphrases
- idiopathic pulmonary fibrosis
- poor prognosis
- risk factors
- simultaneous determination
- end stage renal disease
- interstitial lung disease
- newly diagnosed
- chronic kidney disease
- long non coding rna
- mass spectrometry
- ejection fraction
- magnetic resonance
- liquid chromatography
- chronic obstructive pulmonary disease
- computed tomography
- cardiovascular disease
- coronary artery disease
- acute coronary syndrome
- cardiovascular events
- intensive care unit
- tandem mass spectrometry
- patient reported outcomes
- systemic sclerosis
- solid phase extraction
- atrial fibrillation
- percutaneous coronary intervention
- contrast enhanced
- mechanical ventilation