Hepatic-specific Pgc-1α ablation drives fibrosis in a MASH model.
Maria ArconzoElena PiccininEmanuela PasculliMarica CarielloNicolas LoiseauJustine Bertrand-MichelHervé GuillouMaria L MatrellaGaetano VillaniAntonio MoschettaPublished in: Liver international : official journal of the International Association for the Study of the Liver (2024)
In a MASH model the hepatic ablation of Pgc-1α drives fibrosis independently from lipid and glucose metabolism. These results add a novel mechanistic piece to the puzzle of the specific and crucial role of mitochondrial function in MASH development.