Progesterone modulates extracellular heat-shock proteins and interlukin-1β in human choriodecidual after Escherichia coli infection.
Janelly Estefania Palacios-LunaMariana Victoria López-MarrufoGerardo Bautista-BautistaCinthia Selene Velarde-GuerraGraciela Villeda-GabrielOscar Flores-HerreraMauricio Osorio-CaballeroJose Carlos Aguilar-CarrascoMartha Leticia Palafox-VargasGuadalupe García-LópezOscar Díaz-RuízFabián Arechavaleta-VelascoHector Flores-HerreraPublished in: Placenta (2023)
we found that progesterone modulates the anti-inflammatory (eHsp-27) and pro-inflammatory (eHsp-60 and eHsp-70) levels of eHsp induced by E. coli infection in human choriodecidual tissue. eHsp-60 and eHsp-70 levels were not completely reversed; maintaining the secretion of IL-1β, which has been associated with adverse events during pregnancy.