Early and sustained Lactobacillus plantarum probiotic therapy in critical illness: the randomised, placebo-controlled, restoration of gut microflora in critical illness trial (ROCIT).
Edward LittonMatt AnsteyDavid BroadhurstAndy ChapmanAndrew CurrieJanet FerrierJoel GummerAlisa HigginsJolene LimLaurens ManningErina MyersKatrina OrrAnne-Marie PalermoAndrea PapariniSusan PellicanoEdward RabyAnu RammohanAdrian RegliBernhard RichterSam SalmanTobias StrunkSharon WatersonDavid WeightBradley WibrowFiona WoodPublished in: Intensive care medicine (2021)
Early and sustained untargeted administration of probiotic therapy with Lactobacillus plantarum 299v to adult patients admitted to the ICU is safe, but not associated with improved patient outcomes.
Keyphrases
- placebo controlled
- study protocol
- clinical trial
- double blind
- phase iii
- phase ii
- open label
- intensive care unit
- mass spectrometry
- randomized controlled trial
- squamous cell carcinoma
- bacillus subtilis
- bone marrow
- high resolution mass spectrometry
- mesenchymal stem cells
- extracorporeal membrane oxygenation
- replacement therapy