Transcriptomic profiling and genomic rearrangement landscape of Nigerian prostate cancer.

Yusuph MavuraHanbing SongJamie XiePablo TamayoAbdullahi MohammedAhmad T LawalAhmad BelloSani IbrahimMohammed FarukFranklin W Huang

Published in: The Prostate (2023)

Less frequent ETS fusion events other than TMPRSS2-ERG such as TMPRSS2-ETV5 and non-ETS fusion events such as SLC45A3-SKIL may be more common in PCa in Nigerian men. This study provides useful working transcriptomic signatures that characterize oncogenic states representative of specific gene fusion events in PCa from Nigerian men.

Keyphrases

single cell
prostate cancer
transcription factor
rna seq
copy number
genome wide
middle aged
radical prostatectomy
cross sectional
genome wide identification
dna methylation