Role of the ABCA4 Gene Expression in the Clearance of Toxic Vitamin A Derivatives in Human Hair Follicle Stem Cells and Keratinocytes.
Aneta ŚcieżyńskaKrzysztof ŁuszczyńskiMarcin RadziszewskiMichał KomorowskiMarta SoszyńskaNatalia KrześniakKateryna ShevchenkoAnna LutyńskaJacek MalejczykPublished in: International journal of molecular sciences (2023)
The ABCA4 gene encodes an ATP-binding cassette transporter that is expressed specifically in the disc of photoreceptor outer segments. Mutations in the ABCA4 gene are the main cause of retinal degenerations known as " ABCA4 -retinopathies." Recent research has revealed that ABCA4 is expressed in other cells as well, such as hair follicles and keratinocytes, although no information on its significance has been evidenced so far. In this study, we investigated the role of the ABCA4 gene in human keratinocytes and hair follicle stem cells for the first time. We have shown that silencing the ABCA4 gene increases the deleterious effect of all-trans-retinal on human hair follicle stem cells.
Keyphrases
- stem cells
- endothelial cells
- gene expression
- genome wide
- copy number
- induced pluripotent stem cells
- pluripotent stem cells
- optical coherence tomography
- dna methylation
- diabetic retinopathy
- genome wide identification
- healthcare
- cell therapy
- cell proliferation
- high resolution
- genome wide analysis
- social media
- mass spectrometry
- single cell
- transcription factor
- endoplasmic reticulum stress
- bone marrow