The role of chaperone-mediated autophagy in neurotoxicity induced by alpha-synuclein after methamphetamine exposure.

Leping SunYongling LianJiuyang DingYunle MengChen LiLing Chen Pingming Qiu

Published in: Brain and behavior (2019)

The results provide in vivo evidence for CMA plays a pivotal role in METH-induced neurotoxicity, and upregulation of Hsc70 expression significantly protects neuronal cells against METH-induced toxicity. This research may pave the way for potential therapeutic approaches targeting CMA for METH abuse and neurodegenerative disorders.

Keyphrases

diabetic rats
high glucose
poor prognosis
oxidative stress
induced apoptosis
signaling pathway
cell death
endoplasmic reticulum stress
cell cycle arrest
drug induced
endothelial cells
drug delivery
cancer therapy
binding protein