Treatment and outcomes in children with multidrug-resistant tuberculosis: A systematic review and individual patient data meta-analysis.
Elizabeth Page HarauszAnthony J Garcia-PratsStephanie LawH Simon SchaafTamara KredoJames A SeddonDick MenziesAnna TurkovaJay AcharFarhana AmanullahPennan BarryMercedes BecerraEdward D ChanPei Chun ChanDomnica Ioana ChiotanAldo CrossaPeter C DrobacLee FairlieDennis FalzonJennifer FloodMedea GegiaRobert M HicksPetros IsaakidisS M KadriBeate KampmannShabir A MadhiElse MaraisAndrei MariandyshevAna Méndez-EchevarríaBrittany Kathryn MooreParpieva NargizaIveta OzereNesri PadayacthiSaleem- Ur-RehmanNatasha RybakBegoña Santiago-GarciaN Sarita ShahSangeeta SharmaTae Sun ShimAlena SkrahinaAntonio Soriano-ArandesMartin van den BoomMarieke J van der WerfTjip S van der WerfBhanu WilliamsElena YablokovaJae-Joon YimJennifer FurinAnneke C Hesselingnull nullPublished in: PLoS medicine (2018)
This study suggests that children respond favorably to MDR-TB treatment. The low success rate in children infected with HIV who did not receive ART during their MDR-TB treatment highlights the need for ART in these children. Our findings of individual drug effects on treatment outcome should be further evaluated.
Keyphrases
- multidrug resistant
- young adults
- systematic review
- mycobacterium tuberculosis
- hiv infected
- antiretroviral therapy
- randomized controlled trial
- type diabetes
- hepatitis c virus
- human immunodeficiency virus
- combination therapy
- hiv aids
- hiv positive
- electronic health record
- acinetobacter baumannii
- deep learning
- pseudomonas aeruginosa
- adipose tissue
- skeletal muscle
- gram negative
- case report
- artificial intelligence
- glycemic control
- hiv testing
- adverse drug
- data analysis