Upregulation of HLA-E by dengue and not Zika viruses.

Elena DrewsAwadalkareem AdamPhone HtooElizabeth TownsleyAnuja Mathew

Published in: Clinical & translational immunology (2018)

Our results suggest that while DENV infection induces HLA-E, the high MHC class I expression on uninfected and infected HMEC-1 cells may dominate the diverse signals generated between inhibitory and activating receptors on NK cells and ligands on target cells.

Keyphrases

induced apoptosis
dengue virus
zika virus
cell cycle arrest
poor prognosis
signaling pathway
nk cells
endoplasmic reticulum stress
aedes aegypti
cell proliferation
hiv infected
cell death
antiretroviral therapy