The Effects of Acute and Chronic Alcohol Administration and Withdrawal on Bone Microstructure, Mechanical Strength, and Remodeling Protein Expression and Their Relation to an Antioxidant and FGF23 In Vivo.
Syed Alhafiz Syed HashimIsa Naina MohamedNorazlina MohamedPublished in: Biomedicines (2024)
Alcohol's detrimental effects on bone health are well established, yet some literature suggests moderate consumption may offer benefits. With alcohol use on the rise, we investigate the impact of acute and chronic alcohol administration, along with withdrawal, on male Wistar rat femurs. We observed a transient cortical thickness increase with acute alcohol (AA) compared to chronic exposure (CA) but no significant changes in trabecular parameters or mechanical properties. High osteocalcin and osteopontin expression levels were noted in AA, alongside elevated RANKL expression. Conversely, CA showed low TRAP levels. FGF23 expression significantly increased during alcohol withdrawal (AW), while GPX decreased after chronic exposure but rose during withdrawal. Although mechanical strength changes were insignificant, biochemical shifts suggest alcohol exposure promotes bone resorption, reduces antioxidant protection, and potentially hampers active vitamin D and phosphate reabsorption via FGF23 upregulation.
Keyphrases
- poor prognosis
- alcohol consumption
- liver failure
- drug induced
- bone mineral density
- oxidative stress
- respiratory failure
- public health
- healthcare
- systematic review
- cell proliferation
- binding protein
- mental health
- soft tissue
- signaling pathway
- anti inflammatory
- high intensity
- immune response
- body composition
- human health
- postmenopausal women
- social media
- nuclear factor
- mechanical ventilation
- inflammatory response