Novel role of Tieg1 in muscle metabolism and mitochondrial oxidative capacities.
Malek KammounJerome PiquereauLydie Nadal-DesbaratsSandra MêmeMaud BeuvinGisèle BonneVladimir VekslerYann Le FurPhilippe PouletautWilliam MêmeFrederic SzeremetaJean-Marc ConstansElizabeth S BruinsmaMolly H Nelson HolteZeynab NajafovaSteven A JohnsenMalayannan SubramaniamJohn R HawseSabine F BensamounPublished in: Acta physiologica (Oxford, England) (2019)
Our findings have implicated novel roles for Tieg1 in muscle including regulation of gene expression, metabolic activity and organization of tissue ultrastructure. This muscle phenotype resembles diseases associated with exercise intolerance and myopathies of unknown consequence.