Simultaneous Positron Emission Tomography and Molecular Magnetic Resonance Imaging of Cardiopulmonary Fibrosis in a Mouse Model of Left Ventricular Dysfunction.
Brianna F MoonIris Yuwen ZhouYingying NingYinching Iris ChenMariane Le FurSergey ShuvaevEman A AkamHua MaCesar Molinos SolsonaJonah Weigand-WhittierNicholas RotileLida P HaririMatthew DrummondAvery T BoiceSamantha E ZygmontYamini SharmaRod R WarburtonGregory L MartinRobert M BlantonBarry L FanburgNicholas S HillPeter CaravanKrishna C PenumatsaPublished in: Journal of the American Heart Association (2024)
Administration of collagen-targeted PET and allysine-targeted MR probes led to elevated PET-magnetic resonance imaging signals in the myocardium and lungs of TAC mice. The study demonstrates the potential to detect fibrosis and fibrogenesis in cardiopulmonary disease through a dual molecular PET-magnetic resonance imaging protocol.
Keyphrases
- positron emission tomography
- computed tomography
- magnetic resonance imaging
- contrast enhanced
- pet ct
- mouse model
- pet imaging
- left ventricular
- cancer therapy
- randomized controlled trial
- heart failure
- single molecule
- oxidative stress
- diffusion weighted imaging
- acute myocardial infarction
- small molecule
- type diabetes
- mitral valve
- high fat diet induced
- photodynamic therapy
- liver fibrosis
- hypertrophic cardiomyopathy
- acute coronary syndrome
- aortic stenosis
- human health
- living cells
- fluorescence imaging
- nucleic acid
- left atrial
- wound healing