Human Rhinovirus/Enterovirus in Pediatric Acute Respiratory Distress Syndrome.
Michele E SmithPatrick T WilsonPublished in: Journal of pediatric intensive care (2019)
The role of human rhinovirus/enterovirus (HRV/HEV) in severe lower respiratory tract infections remains unclear. We characterized the respiratory status of children admitted to a large academic pediatric intensive care unit (PICU) who tested positive for only HRV/HEV. One hundred and fifty-five children met inclusion criteria with 62% requiring positive pressure respiratory support of 5 cm of water pressure or more within the first 24 hours of admission. Among them, 34% had SaO 2 to FiO 2 ratios of 264 or less with 22 patients (14%) meeting criteria for pediatric acute respiratory distress syndrome. HRV/HEV is associated with significant respiratory disease in children admitted to the PICU.
Keyphrases
- acute respiratory distress syndrome
- mechanical ventilation
- extracorporeal membrane oxygenation
- respiratory tract
- intensive care unit
- endothelial cells
- young adults
- end stage renal disease
- emergency department
- ejection fraction
- chronic kidney disease
- induced pluripotent stem cells
- newly diagnosed
- pluripotent stem cells
- early onset
- tyrosine kinase
- patient reported outcomes
- childhood cancer