The HDAC inhibitor domatinostat induces type I interferon α in Merkel cell carcinoma by HES1 repression.

Nalini SrinivasLina SongKuan Cheok LeiJan GravemeyerFrauke FurtmannThilo GambichlerJürgen Christian BeckerAshwin Sriram

Published in: Journal of cancer research and clinical oncology (2023)

Our results demonstrate that the direct anti-tumor effect of HDACi domatinostat on MCC cells is at least in part mediated via decreased HES1 expression allowing the induction of IFNα, which in turn causes apoptosis.

Keyphrases

cell cycle arrest
induced apoptosis
endoplasmic reticulum stress
cell death
dendritic cells
poor prognosis
pi k akt
oxidative stress
immune response
fluorescent probe
histone deacetylase
sensitive detection
binding protein
cell proliferation