Identification of Proteomic Markers in Head and Neck Cancer Using MALDI-MS Imaging, LC-MS/MS, and Immunohistochemistry.

Franziska HoffmannClaudia UmbreitThomas KrügerDaniela PelzelGünther ErnstOlaf KniemeyerOrlando Guntinas-LichiusAlexander BerndtFerdinand von Eggeling

Published in: Proteomics. Clinical applications (2018)

The combination of MALDI-MSI, LC-MS/MS, and subsequent IHC furnishes a tool suitable for characterizing the molecular heterogeneity of tissue. It is also suited for use in identifying new representative biomarkers to enable a more individualized therapy.

Keyphrases

mass spectrometry
high resolution
single cell
cross sectional
multiple sclerosis
single molecule
bioinformatics analysis
label free
stem cells
mesenchymal stem cells
bone marrow