Melatonin protects mesenchymal stem cells from autophagy-mediated death under ischaemic ER-stress conditions by increasing prion protein expression.
Jun Hee LeeYeo Min YoonYong-Seok HanSeo Kyung JungSang-Hun LeePublished in: Cell proliferation (2018)
Melatonin protects against ER stress/autophagy-induced apoptotic cell death by augmenting PrPC expression. Thus, melatonin-treated MSCs could be a potential cell-based therapeutic agent for ER stress-induced ischaemic diseases, and melatonin-induced PrPC might be a key molecule in ameliorating ER stress and autophagy.
Keyphrases
- cell death
- stress induced
- mesenchymal stem cells
- high glucose
- diabetic rats
- cell cycle arrest
- endoplasmic reticulum stress
- oxidative stress
- signaling pathway
- umbilical cord
- poor prognosis
- cell therapy
- single cell
- stem cells
- endothelial cells
- estrogen receptor
- breast cancer cells
- risk assessment
- binding protein
- pi k akt
- endoplasmic reticulum