Using Pooled Electronic Health Records Data to Conduct Pharmacoepidemiology Safety Studies: Challenges and Lessons Learned.

Timothy BeukelmanLang ChenNarender AnnapureddyJim OatesMegan E B ClowseMillie LongMichael D KappelmanRennie L RheePeter A MerkelWilliam Benjamin NowellFenglong XieCassie ClintonJeffrey R Curtis

Published in: Pharmacoepidemiology and drug safety (2023)

EHR data substantially misclassified TNFi exposure and underestimated the incidence of hospitalized infections compared to claims data. EHR-based new user definitions were reasonably accurate. Overall, using CRN data for pharmacoepidemiology studies is challenging, especially for biologics, and would benefit from supplementation by other sources. This article is protected by copyright. All rights reserved.

Keyphrases

electronic health record
clinical decision support
adverse drug
big data
clinical trial
risk factors
randomized controlled trial
case control
data analysis