Ablation of Cancer Stem Cells by Therapeutic Inhibition of the MDM2-p53 Interaction in Mucoepidermoid Carcinoma.
April AndrewsKristy WarnerChristie Rodriguez-RamirezAlexander T PearsonFelipe NörZhaocheng ZhangSamuel KerkAditi KulkarniJoseph I HelmanJohn Chad BrennerMax S WichaShaomeng WangJacques E NörPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
Collectively, these data demonstrate that MI-773 reduces the fraction of CSCs, suggesting that patients with mucoepidermoid carcinoma might benefit from therapeutic inhibition of the MDM2-p53 interaction.