Analysis of clinical cure outcome, macrophages number, cytokines levels and expression of annexin-A1 in the cutaneous infection in patients with Leishmania braziliensis.

Joselina Maria da Silva Helen Aguiar Lemes da Silva Ana Lucia Carneiro Sarmento Marcia Hueb Amílcar Sabino Damazo

Published in: Revista da Sociedade Brasileira de Medicina Tropical (2024)

These findings suggest that the infectious microenvironment induced by L. braziliensis affects the differentiation of M1 and M2 macrophages, cytokine release, and ANXA1 expression, thereby influencing the healing capacity of patients. Therefore, histopathological and immunological investigations may improve the selection of CL therapy.

Keyphrases

poor prognosis
end stage renal disease
newly diagnosed
chronic kidney disease
stem cells
peritoneal dialysis
binding protein
prognostic factors
long non coding rna
mesenchymal stem cells
patient reported outcomes