Igalan from Inula helenium (L.) suppresses the atopic dermatitis-like response in stimulated HaCaT keratinocytes via JAK/STAT3 signaling.

Thien T P DaoKwangho SongJee Young KimYeong Shik Kim

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2020)

These findings indicate that igalan, via suppressing JAK/STAT3 signaling, could impair the production of pro-inflammatory chemokines and enhance expression levels of several genes involved in keratinocyte differentiation in AD-like stimulated keratinocytes.

Keyphrases

atopic dermatitis
signaling pathway
poor prognosis
binding protein
long non coding rna