Long Non-Coding RNAs in Sjögren's Disease.
Ondřej PastvaKerstin KleinPublished in: International journal of molecular sciences (2024)
Sjögren's disease (SjD) is a heterogeneous autoimmune disease characterized by severe dryness of mucosal surfaces, particularly the mouth and eyes; fatigue; and chronic pain. Chronic inflammation of the salivary and lacrimal glands, auto-antibody formation, and extra-glandular manifestations occur in subsets of patients with SjD. An aberrant expression of long, non-coding RNAs (lncRNAs) has been described in many autoimmune diseases, including SjD. Here, we review the current literature on lncRNAs in SjD and their role in regulating X chromosome inactivation, immune modulatory functions, and their potential as biomarkers.
Keyphrases
- long non coding rna
- poor prognosis
- chronic pain
- systematic review
- oxidative stress
- multiple sclerosis
- escherichia coli
- optical coherence tomography
- disease activity
- physical activity
- early onset
- systemic lupus erythematosus
- risk assessment
- transcription factor
- dna methylation
- staphylococcus aureus
- peripheral blood
- network analysis
- depressive symptoms
- pain management