Cholesterol profiling reveals 7β-hydroxycholesterol as a pathologically relevant peripheral biomarker of Alzheimer's disease.

Junghee HaGo Eun KwonYumi SonSoo Ah JangSo Yeon ChoSoo Jin ParkHyunjeong KimJimin LeeJuseok LeeDongryul SeoMyeongjee LeeDo Yup LeeMan Ho ChoiEosu Kim

Published in: Psychiatry and clinical neurosciences (2024)

Our results suggest that 7β-OHC could serve as a convenient, peripheral biomarker of AD. As directly involved in AD pathogenesis, 7β-OHC assay may help actualize personalized medicine in a way to identify an at-risk subgroup as a candidate population for statin-based AD treatment.

Keyphrases

low density lipoprotein
cardiovascular disease
chemotherapy induced
coronary artery disease
cognitive decline
single cell
type diabetes
randomized controlled trial