Therapeutic plasma exchange for the management of severe gestational hypertriglyceridaemic pancreatitis due to lipoprotein lipase mutation.
Albert S KimRashida HakeemAzaliya AbdullahAmanda J HooperMichel C TchanThushari I AlahakoonChristian M GirgisPublished in: Endocrinology, diabetes & metabolism case reports (2020)
Hormonal changes in pregnancy, mediated by progesterone,oestrogen and human placental lactogen, lead to a two- to three-fold increase in serum triglyceride levels. Pharmacological intervention for management of gestational hypertriglyceridaemia rely on the augmentation of lipoprotein lipase (LPL) activity to enhance catabolism of triglyceride-rich lipoproteins. Genetic mutations affecting the LPL gene can lead to severe hypertriglyceridaemia. Therapeutic plasma exchange (TPE) is an effective intervention for the management of severe gestational hypertriglyceridaemia and should be considered in cases where there is an underlying LPL defect. Preconception counselling and discussion regarding contraception is of paramount importance in women with familial hypertriglyceridaemia.
Keyphrases
- weight gain
- pregnant women
- early onset
- randomized controlled trial
- pregnancy outcomes
- genome wide
- low density lipoprotein
- type diabetes
- copy number
- physical activity
- hepatitis c virus
- preterm birth
- skeletal muscle
- induced pluripotent stem cells
- human immunodeficiency virus
- polycystic ovary syndrome
- hiv infected
- insulin resistance