Inhibition of DNA methylation derepresses PPARγ and attenuates pulmonary fibrosis.

Ai WeiQi GaoFang ChenXiaobo ZhuXingren ChenLijun ZhangXin SuJinghong DaiYi ShiWangsen Cao

Published in: British journal of pharmacology (2021)

Aberrant DNMT1/3a elevations and the resultant PPARγ suppression contribute significantly to the development of pulmonary fibrosis, and strategies targeting DNMT/PPARγ axis by synthetic or natural small compounds might benefit patients with pulmonary fibrotic disorders.

Keyphrases

pulmonary fibrosis
dna methylation
insulin resistance
genome wide
gene expression
fatty acid
pulmonary hypertension
systemic sclerosis
idiopathic pulmonary fibrosis
type diabetes
cancer therapy
skeletal muscle
metabolic syndrome
drug delivery