Genetic QT Score and Sleep Apnea as Predictors of Sudden Cardiac Death in the UK Biobank.

Amit AroraWojciech ZarebaRaymond L WoosleyYann C KlimentidisImran Y PatelStuart F QuanChristopher WendelFadi Elias ShamounStefano GuerraSairam ParthasarathySalma Imran Patel

Published in: medRxiv : the preprint server for health sciences (2023)

In the UK Biobank population, the QTc-PRS was associated with SCD among participants with sleep apnea but not among those without sleep apnea, indicating that sleep apnea is a significant modifier of the genetic risk. Black participants with sleep apnea had a particularly high risk of SCD.

Keyphrases

sleep apnea
positive airway pressure
obstructive sleep apnea
genome wide
cross sectional
copy number
gene expression