The chemokine lymphotactin and its recombinant variants in oral cancer cell regulation.

Amir Zaki Abdullah ZubirSimon A WhawellTuck Seng WongSyed Ali Khurram

Published in: Oral diseases (2020)

The development of hLtn biological mutants, regulation of XCR1 expression by its ligand hLtn and crosstalk with fibroblasts are novel findings suggesting an important role for the XCR1/hLtn axis within the OSCC tumour microenvironment. These discoveries build upon previous studies and suggest that the hLtn/XCR1 axis has a significant role in stromal crosstalk and OSCC progression.

Keyphrases

poor prognosis
stem cells
copy number
gene expression
dna methylation
case control
genome wide