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miR-142-3p as tumor suppressor miRNA in the regulation of tumorigenicity, invasion and migration of human breast cancer by targeting Bach-1 expression.

Behzad MansooriAli MohammadiMehri GhasabiSolmaz ShirjangRazeieh DehghanVahid MontazeriUffe HolmskovTohid KazemiPascal H G DuijfMorten Frier GjerstorffBehzad Baradaran
Published in: Journal of cellular physiology (2018)
For the first time, our results revealed that miR-142-3p could target Bach-1in breast cancer cells leading to the reduction of EMT-related proteins and reduced cell proliferation, invasion, and migration. The results also demonstrated that miR-142-3p could regulate important tumor suppressor miRNAs in breast cancer cells. In conclusion, our results suggest that miR-142-3p could be a good candidate for the targeted therapy of breast cancer, especially for the invasive type.
Keyphrases
  • breast cancer cells
  • cell proliferation
  • cell migration
  • endothelial cells
  • poor prognosis
  • epithelial mesenchymal transition
  • cell cycle
  • induced pluripotent stem cells