Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism

Güven Yenmiş Nail Beşli Elif Yaprak Saraç Fatma Sinem Hocaoğlu Emre Kazım Şenol Gonul Kanigur Sultuybek

Published in: Turkish journal of medical sciences (2021)

Metformin can modulate cyclin D1 and p53 expression through AMPK-alpha-independent mechanism in breast cancer cells, leading to cell proliferation inhibition and apoptosis induction.

Keyphrases

breast cancer cells
cell cycle arrest
cell proliferation
pi k akt
cell cycle
cell death
poor prognosis
signaling pathway
endoplasmic reticulum stress
oxidative stress
skeletal muscle
protein kinase
long non coding rna
binding protein