Ferroptosis is a novel form of programmed cell death characterized by the accumulation of iron-dependent lipid peroxides, which causes membrane injury. Under the catalysis of iron ions, cells deficient in glutathione peroxidase (GPX4) cannot preserve the balance in lipid oxidative metabolism, and the buildup of reactive oxygen species on the membrane lipids leads to cell death. An increasing body of evidence suggests that ferroptosis plays a significant role in the development and occurrence of cardiovascular diseases. In this paper, we mainly elaborated on the molecular mechanisms regulating ferroptosis and its impact on cardiovascular disease to lay the groundwork for future studies on the prophylaxis and treatment of this patient population.
Keyphrases
- cell death
- cardiovascular disease
- cell cycle arrest
- reactive oxygen species
- fatty acid
- induced apoptosis
- cardiovascular events
- type diabetes
- cardiovascular risk factors
- risk assessment
- case report
- signaling pathway
- iron deficiency
- coronary artery disease
- quantum dots
- endoplasmic reticulum stress
- metabolic syndrome
- case control